Douglas Laboratories have created a very resourceful multivitamin called Ultra Preventive X (Tablets version). It is considered to be their signature supplement providing “antioxidant equivalent of 4-5 servings of fruits and vegetables, along with bioavailable forms of vitamins, minerals, trace elements and beneficial nutrients” [R, R].
Furthermore, it is claimed to “contain the right proportions of vitamins, minerals, trace elements, and other nutrients without danger of toxic build-up or other side effects”. As well as it is asserted that“each ingredient is selected in consideration of its absorbability, competitive relationship with other nutrients, allergenic potential, and longterm safety” [R, R].
In this Douglas Laboratories Ultra Preventive X review, we are going to explore the supplement’s ingredients to actually determine if that is a supplement you should consider.
Vitamins Are All You’d Ever Want, Even Maybe Too Much
Douglas Laboratories Ultra Preventive X contains incredible amounts of all of the needed vitamins except for Vitamin K1. Also, the vitamin forms for most vitamins are the best available.
A thing worth mentioning is that, although Vitamin K1 is not present as an active ingredient, it is not completely non-existent in the supplement as a whole. Certain amounts of Vitamin K1 contains many substances of the other beneficial substances segment, for example, Rose Hips, Blackberry (fruit), Proprietary Organic Fruit and Vegetable Blend and other.
Both of Vitamin A components (preformed form and carotenoids) are in very, very great shape providing everything one could ask for. In fact, this supplement has all forms of carotenoids (Alpha, Beta, Cryptoxanthin, Zeaxanthin, Lutein, and even Lycopene) within it. Nonetheless, Lycopene will be discussed separately later [R, R, R, R, R, R, R, R, R, R].
Vitamin B2, B3, and B7 are among the best choices for each respective vitamin. The other form of Vitamin B3 is basically as effective as the free form. And supposedly also the free form of Vitamin B1 is one of the two best choices for the intake of this vitamin [R, R, R, R, R, R, R, R, R, R, R, R, R, R].
Vitamin B5, B9, B12 and D – all of these are present in the best forms possible. But Vitamin B6 and C at the same time are each available in multiple forms, of which some are the best and most effective forms possible [R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R].
A thing to know is that actually Vitamin E is associated with 8 different compounds: 4 tocopherols and 4 tocotrienols. Ultra Preventive X is very abundant in tocopherols but does not contain any of the tocotrienols. Nonetheless, having at least 4 of the 8 Vitamin E compounds in a multivitamin supplement is extremely good [R, R, R].
All The Necessary Daily Minerals To Make You Great Are Present
Douglas Laboratories Ultra Preventive X contains all of the essential and daily needed minerals and trace elements, no exception. In fact, not only will it provide you with Calcium, Iodine, Magnesium, Zinc, Selenium, Copper, Manganese, Chromium, Molybdenum, Potassium, Boron, and Vanadium, but also with additional trace elements from Sea Vegetation. There is really nothing else you would need from a supplement.
Calcium, Magnesium, Manganese, Potassium, and Boron here all are present in many various forms for each respective mineral and trace element. Some are not that great, the others, however, are no less than awesome for intake and benefit [R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R].
Zinc and Copper are present in the form of amino acid chelate. Which is great in spite of the particular amino acid chelates not being specified. Nonetheless, any amino acid chelate form is supposedly a pretty good choice to go for [R, R, R, R, R, R].
Selenium, Molybdenum, and Vanadium each come in a 5 different form complex. None of the forms are the best forms for any respective mineral. The fact that they partly imitate Krebs Cycle (sequence of reactions for generation of energy within living cells) and might be wrong here, but from what I gather, it is in no way beneficial to the Krebs Cycle itself [R, R, R]. Definitely let me know in the comments if you have more knowledge on this.
Chromium comes in the form of being organically bound with GTF (Glucose Tolerance Factor). Although this is not the most bioavailable form of Chromium, it is, however, among the most beneficial ones. This is because it has some amazing additional benefits what regards itself [R, R, R, R].
Thus, all in all the only slight issue that there is, is that Calcium is slightly lacking in terms of amounts (see Prime Daily Values).
Great Additions For Those Extra Improvements
Douglas Laboratories Ultra Preventive X is quite abundant in regards to additional beneficial substances. It contains the following beneficial substances: Inositol, Para-Aminobenzoic Acid (PABA), L-Cysteine/N-Acetyl L-Cysteine, Betaine, Bromelain, Glutamic Acid, L-Methionine, Rose, Hips, Lemon Bioflavonoids, Red Wine Proanthocyanidins/Pine Bark Extract, Hesperidin, Rutin, Proprietary Organic Fruit and Vegetable Blend, Garlic, Cauliflower (entire plant), Spirulina, Chlorella (broken cell wall), Green Papaya Extract (fruit), Blackberry (fruit), Celery Powder (leaf), Black Radish Powder (root), Apricot Powder (fruit), Green Tea Extract (leaf) and Apple Pectin (fruit).
Inositol is a substance, which greatly improves brain function. It also helps to calm one’s mind as well as scientifically proven to ease depression, panic attacks, anxiety and provides other benefits [R, R, R, R, R, R, R, R, R, R].
L-Cysteine/N-Acetyl L-Cysteine. Although it has many, many other benefits, the main, pivotal and most important benefit of the substance is that it helps the body to improve the amounts of Glutathione. Essentially, it is a semi-essential amino acid, which the body can produce, but only in small amounts. Therefore it is very important to get additional amounts of it, if possible [R, R, R, R, R, R].
The substance called Glutathione is the best antioxidant of all antioxidants there is. Period. One could simply list all the benefits it provides, but it might take forever. The essential thing to understand is that it helps every cell in the body to be protected and healthy, which is incredibly important in nowadays environment [R, R, R, R, R, R].
Betaine is an amino acid that is produced by the body (also called Trimethylglycine). Betaine has a vital role in the methylation process in the body. And because of that, it is extremely important for the body and mind to function well and at its best [R, R, R].
Bromelain is an enzyme found in pineapples. It provides with such benefits as improving digestive health, reducing inflammation, pain, and swelling. It also fights off cancer, promotes weight loss and has other benefits [R, R].
Rose Hips is a very nutrient-dense substance providing loads of different nutrients: Calcium, Iron, Magnesium, Phosphorus, Potassium, Sodium, Zinc, various carotenoids, as well as Vitamin B1, B2, B3, B6, C, E, and K1. From all of the mentioned, Rose Hips are especially abundant in Vitamin C [R, R, R].
Nonetheless, Rose Hips are known to have some pretty nice benefits. It prevents cancer, lowers cholesterol levels, improves digestion and heart health and among some other has great anti-inflammatory abilities [R, R, R, R].
Lemon Bioflavonoids basically are the same as citrus bioflavonoids, except they are exclusively harvested from lemons. Citrus bioflavonoids are known to have amazing overall anti-inflammatory abilities. Substances like Hesperidin (also a bioflavonoid) are also known to protect the brain against memory impairment and various types of insult, as well as prevent depressive behavior [R, R, R, R, R].
Another bioflavonoid found in the Douglas Laboratories Ultra Preventive X is Rutin. Rutin is known to improve the health of blood vessels, which consequently can improve overall health. For example, prevent heart attacks, stroke, and thrombosis. Rutin also as any other bioflavonoid possesses anti-inflammatory and antioxidant qualities, and it also lowers the “bad” cholesterol levels [R, R, R, R, R, R, R, R, R].
Yet another flavonoid found in the supplement is Proanthocyanidins extract (from Red Wine and Pine Bark) [R]. As with any flavonoid it also displays strong antioxidative properties – among others it offers protection against atherosclerosis, cancer and heart disease [R, R, R, R, R, R, R].
Proprietary Organic Fruit and Vegetable Blend are full of organic powders of fruits and vegetables. And essentially, (just like the real thing) they will provide you with all of the nutrients of those fruits and vegetables. This means lots of Dietary Fibre, Amino Acids, good amounts of extra vitamins and minerals [R].
Garlic (also very abundant in nutrients) helps to combat sickness, can reduce blood pressure, improves cholesterol levels, has antioxidative properties, helps to detoxify heavy metals, potentially also fight against cancer and has many other benefits [R, R, R, R, R].
Cauliflower (entire plant) helps to fight cancer, provides with anti-inflammatory, antioxidative and detoxification associated benefits, has great nutritional value, is a great source of Choline (boosts brain health), helps to preserve eye health and has loads of other benefits [R, R, R, R].
Spirulina is often referred to as one of the world’s superfoods. And this is no wonder. There are very many benefits to this incredibly healthy plant. In my opinion, some of the most significant benefits are: it provides with loads of various vitamins, minerals, proteins, amino acids, and essential fatty acids, it helps to detoxify heavy metals from the body, improve blood sugar levels, immunity, as well as helps to fight off cancer, also lowers “bad” cholesterol levels and in its very essence is an amazing antioxidant [R, R, R, R, R, R, R, R, R, R, R, R, R, R].
But I’m going to repeat myself, consuming Spirulina has many, many, many more benefits.
In that regard Chlorella is a very close relative to Spirulina, and it is also considered a superfood. Similarly, as Spirulina, Chlorella is a very nutritious plant (very, very abundant in Amino Acids). Among many other benefits, Chlorella detoxifies heavy metals and radiation (also chemotherapy), supports the immune system, helps against cancer, lowers blood sugar and cholesterol levels [R, R, R, R].
Green Papaya Extract (fruit), Blackberry (fruit), Apricot Powder (fruit) and Apple Pectin (fruit) essentially are all very nutritious and are very potent antioxidants. However, they do have some additional benefits [R].
For example, Papaya also improves digestion, fights inflammation and improves heart health [R, R, R, R]. On the other hand, Blackberries are, for example, known for being able to fight off cancer, improving brain function and boosting overall immunity [R, R, R].
Celery Powder (leaf) and Green Tea Extract (leaf) are both very high in anti-oxidants. Celery Powder additionally helps to lower cholesterol, improves liver health, promotes weight loss, boosts digestion and reduces bloating, fights infections, reduces blood pressure, boosts the immune system as a whole and has other benefits [R, R, R, R, R].
Whereas Green Tea offers such benefits as promoting heart, brain and liver health, lowers blood sugar levels, benefits both the exercise performance and recovery after exercise, lowers the risk of some cancers and has other benefits [R, R, R, R].
Black Radish Powder (root) is yet another marvelous antioxidant (I feel I’ve mentioned that just about all beneficial substances). It reduces aging, boosts the function of the liver, regulates cholesterol, helps with bloating, removes kidney stones, increases mental awareness, purifies the skin, promotes weight loss and has other benefits [R, R, R, R].
Additives Completely Safe And Harmless
Also, additive wise Douglas Laboratories Ultra Preventive X is a marvelous thing. None of them are hazardous. Furthermore, contrary to what many might think, that also applies to the Stearic acid.
Cellulose is just about one of the safest additives there is. Cellulose is the natural substance that is found in wood and essentially all plant structures. As for any potential side effects, in big amounts it can cause bloating, constipation and diarrhea [R, R, R, R].
Stearic Acid pretty much falls in the same category as cellulose. However, some think differently, because of the hype on the internet that it promotes cancer or something. But this hype is very unfounded if one immerses oneself into the subject.
All the hype mostly resolves about a single study, in which it was proven that Stearic Acid in large amounts kills off T-cells, which are cells that fight cancer. However, one key thing to mention is that this study was done on rats. And, therefore, while the particular conclusions are true for rats, they are not true for humans [R, R, R, R].
This is because we humans have special enzymes that can deal with Stearic Acid unwanted build-ups and convert it. Rats don’t have that kind of enzymes. A fan fact in this regard is also that human babies consume incredibly large amounts of Stearic Acid through mother’s milk. The kind of amounts we wouldn’t ever be able to consume through the pills of a supplement. Ever [R, R, R, R].
I have heard talks about also some other adverse effects of Stearic Acid. All of which are as easily refutable and not relevant. Therefore, it is safe to say that Stearic Acid is a completely harmless additive that you shouldn’t be afraid of or avoid [R, R, R].
Silica (or Silicon Dioxide) is definitely also among the safest additives out there. It’s a substance very abundant in everything that we know – our bodies, animals, plants, water, as well as the earth itself [R]. Consequently, also studies have shown no long-term threat or adverse effects on health even when silicon dioxide is used in huge amounts [R, R].
Given Supplement’s Potency, Some Special Considerations
Specifically for Ultra Preventive X, I thought it would be appropriate to add a section on special considerations. This is because when we usually look for awesome and beneficial multivitamin supplements, it’s all about it being between the lines of too little of everything and the right amounts you should actually intake, aka Prime Daily Values.
However, with Ultra Preventive X it’s much different in this regard because here Prime Daily Values are the low-point. Meaning the amounts that a single dosage of Ultra Preventive X contains regarding some nutrients exceed the amounts recommended by Prime Daily Values.
And exceeding Prime Daily Values at times is okay, as long as the amounts of a particular nutrient do not exceed what is called the Upper Tolerable Intake Level (UL for short). These are the levels, which essentially define, how much of a particular nutrient is not safe anymore to consume long-term [R, R].
With long-term generally is understood very, very long periods of time. However, I have said it before, and I will say it again, I do feel like it’s rather a case of a lifetime. Anyhow, going over the set UL values would mean to possibly expose oneself to hazardous effects. Hazardous effects that can be caused simply because of the fact that too much a particular nutrient is consumed.
Additionally, I also want to discuss some inaccurate stuff I’ve read on some reviews of Ultra Preventive X. We’ll start with that. And also let me know in the comments below if you feel like there are any other important matters that should be challenged.
Regarding this, I just also wanted to mention that Douglas Laboratories themselves do state that Ultra Preventive X will have no unwanted side effects [R].
Ultra Preventive X does not have too much Vitamin A
Some suggest that one shouldn’t consume Ultra Preventive X just because it has too much Vitamin A within it. However, this is not accurate. Essentially, people that wrote that does not understand the basics of Vitamin A.
If you recall, Vitamin A is not really a single vitamin – it is of two various compounds – retinoids (the preformed retinol) and carotenoids (Alpha-Carotene, Beta-Carotene, Cryptoxanthin, Zeaxanthin, Lutein, Lycopene). Both have their own effects and benefits, both are quite different from the other, but both supplement each other.
In Ultra Preventive X we have 5000 IU of preformed retinol and 21 669 IU of Alpha-Carotene, Beta-Carotene, Cryptoxanthin, Zeaxanthin, Lutein plus 10 000 IU of Lycopene. The UL for Vitamin A is 3000 μg [R, R, R, R].
If we take and convert those 5000 IU to μg, we get 2750. So, if one takes into account the IU of carotenoids, it surely goes beyond the UL value of 3000 μg, therefore, a false conclusion might occur that the supplement contains too much Vitamin A [R].
However, as I mentioned retinoids and carotenoids are not the same thing and should not be put in the same basket. That UL of 3000 μg is actually established specifically for preformed retinol. Carotenoids have their own UL.
Additionally, there are many substances (among the other beneficial substances of the supplement), which seemingly contain amounts of Vitamin A, for example, rose hips. But it’s important to remember that any vitamin A in plants come only in a form of carotenoids. Plants can’t contain preformed retinol, because it can only be acquired either from animal parts or made synthetically [R, R].
Therefore, there is really no way that Vitamin A in a form of preformed retinol can go overboard here. And carotenoids, well one can go overboard with those, however, Ultra Preventive X does not have enough amounts to do that. In fact, the amounts in Ultra Preventive X are congruent with Prime Daily Values [R, R].
Vitamin B3 in Ultra Preventive X might cause some flushing
I’ve seen some indication that there is a possibility of experiencing flushing during the use of Ultra Preventive X. And this actually can be true. This is associated with the amounts of Vitamin B3.
Ultra Preventive X’s label does not indicate how much exactly does the supplement contains of the free form of niacin. It only states that together niacin and niacinamide are in amounts of 190 mg. So, it can be split 50/50 between the two, or it might be that niacinamide is the major part, the other way around wouldn’t really make sense.
The limiting adverse effect for free niacin is recognized as the flushing, which occasionally occurs at doses 30 mg of niacin. However, the report itself also states that “flushing is not a clearly adverse effect”. In fact, it also states that “the most severe and potentially life-threatening adverse effects, such as hepatotoxicity, occur at doses one order of magnitude higher than have been reported for flushing”. This basically means that serious adverse effects are likely to occur only at daily doses of 300 mg of free niacin [R].
The report also specifies, why the flushing occurs and why it should fade on repeated use [R].
Thus, essentially although one may encounter some flushing at first, it should not stick around. But do know that flushing is not like a thing that will most definitely occur. It may or may not occur. I’m just letting you know that, if it does, it won’t affect you negatively in any other way.
What did you mean by “Might Be Too Much”?
If you noticed, earlier in the table I wrote “Might be too much” as an assessment for two of the vitamins, concretely Vitamin B1 and B6. This is because not only the amounts of those greatly surpasses the amounts recommended by Prime Daily Values, but also they might be surpassing the values defined as ULs.
Vitamin B1 even in the amounts of 100 mg/day won’t harm you
Prime Daily Values for Vitamin B1 is at 25-50 mg. Ultra Preventive X has 100 mg. So, is it safe to consume that much?
The European report on ULs does not provide a specific value as there are not enough adequate data to derive UL values (same goes for the U.S. report). However, the European report concludes that orally taken Vitamin B1 has a very low risk of adverse effects. It explains that “This is related to the fact that with intake levels higher than 5 mg absorption rapidly declines and absorbed vitamin B1 is actively excreted in the urine” [R, R].
Additionally, the European report also highlights that Vitamin B1 has been used in amounts of 50-200 mg/day for months without any adverse effects. However, it also points out that there have been some rare cases of adverse effects with the daily dose of 100-300 mg/day. But this dose 100-300 mg/day have been done through injections. Thus, different rules apply than when the vitamin is taken orally [R].
Therefore, I do think that it is safe to say that 100 mg/day orally will do no harm.
It is much different with Vitamin B6 than it was with Vitamin B1
Another vitamin that I want to discuss is Vitamin B6. Prime Daily Values for Vitamin B6 is the same, at 25-50 mg. Ultra Preventive X provides with 100 mg. So, is this safe?
For this one, the European report on ULs does have a specific value, and that is 25 mg. It is derived from a value of 100 mg by applying to it the uncertainty factor of 2×2. In the European report, it is stated that Vitamin B6 in doses of 100 mg is quite likely over long periods of time to cause adverse effects (100 mg/day for more than a year) [R].
Paradoxically, an equivalent U. S. report, however, states that the UL for Vitamin B6 is 100 mg. So, why the differences between the reports [R]?
Well, you can read the long explanation in the European report, but essentially the U. S. report does disregard one study, which although is not flawless, however, provides a good amount of evidence that 100 mg/day is not safe for long periods of time. Also, the U. S. study asserts that 100 mg/day is safe, because of some 4-6 month studies, which in my opinion is not right.
Therefore, I do believe that taking Vitamin B6 in amounts of 100 mg/day over a long period of time will cause severe adverse effects. Thus, it is not safe to consume that much a day. Consequently, that kind of amount also can’t be consumed for the rest of one’s life.
So, where does that leave us?
Well, should you then or should you then not try or use Ultra Preventive X?
Well, that depends on, if you want to experiment or not. There basically are three options you could go for: use it as it is, use it just to try it out or use a safe dose.
Using Ultra Preventive X as it is
Well, if you really want to use the Ultra Preventive X as it is and you have no chronic illnesses, you could try that. The key thing here would be to immediately stop, once you are starting to feel some of the possible adverse effects for having too much of the Vitamin B6 in your system.
Is this safe? More likely yes than no. This is because it is known that any adverse effects if they are not experienced for quite some time, can be easily reversed by simply stopping to take the Vitamin B6. Essentially, our bodies know how to balance it out and get rid of the excess amounts [R].
- An unusual numbness in the body,
- A sensation of tingling anywhere in the body,
- Over-sensitivity to sunlight, which can lead to numbness and skin rashes,
- Nausea, vomiting, abdominal pain, loss of appetite,
- Increased liver function test results,
- Difficulties walking.
Either way, don’t use it for more than a year without a rest period (a time when it’s not used).
All in all, although this is an option, rather not go for it.
Using it to just try it out
Well, I think that this is the way, how one can possibly get the most benefit out of this supplement.
So, the plan would be to use it for 3 months (or up to 6 months) and then cut the daily dose by half or switch to a different multivitamin supplement. Potentially, you could repeat the 3-month thing every year at the same time. This should avoid any unwanted and potentially harmful build up of Vitamin B6 while also letting you experience the full benefits of the supplement.
Nonetheless, you should also watch out for any possible signs that there’s too much Vitamin B6 in your system.
Using a safe dose
The safest way to go about Ultra Preventive X is to simply use a half dose. Or you can also opt for a different multivitamin supplement.
Having the dose for Ultra Preventive X diminished to half will, of course, mean that also all of the other nutrients will be halved. Nonetheless, it still is an impressive multivitamin and definitely one that is worthy taking.
No matter your choice, a key thing to remember is …
We all are different!
Having 100 mg of Vitamin B6 daily for some might not bring any adverse effects. For some even the dose of 200 mg Vitamin B6 daily might not bring any adverse effects. In some very rare cases, 50 mg of Vitamin B6 daily can also bring some adverse effects. 25 mg of Vitamin B6 daily (although never reported) in some extraordinary cases may also bring some symptoms of having too much.
We all are different! Although, we have Prime Daily Values as a generalization as towards what will work for most people to achieve the best health, in some rare cases more nutrients will be needed. In some other cases, slightly less may be needed. And also there are many other factors, which can play a role in how much you need, the most impactful of those – your diet.
Essentially, if you do feel better after using a particular supplement for 1-2 months, stick with that. If not, change it up as there might be of something that is too much or too less in that supplement for you specifically.
At other times, you may feel great, but then trying a new supplement will make you feel even better.
Nonetheless, listen to your body (and mind), they will let you know, what is the best for you!
Ultra Preventive X Is Arguably The Best Multivitamin Out There
To conclude, I have to admit that Douglas Laboratories Ultra Preventive X is, without a shadow of a doubt, an awesome multivitamin supplement.
Essentially, Ultra Preventive X is much like the Prime Daily Values ideal multivitamin supplement. It has loads of everything, great forms of the nutrients most of the time, harmless additives and some really awesome additional beneficial substances.
But do take note that there is a slight problem with the amounts of Vitamin B6 as I indicated in the chapter “Special Considerations”. In essence, it is present in amounts that I do not think are safe for long-term use.
Cutting the supplement dose in half can fix that. Furthermore, even when the doses of everything are halved, it is still an impressive multivitamin supplement, and should not be shied away from.
Whereas, if you’re interested in other great multivitamins or you’re not quite sure, if this supplement is for you, check out the guide I created on the most awesome multivitamins I’ve come across.
If you liked the article, please leave us a comment below – even one sentence helps! And consider including your Twitter handle so I can thank you personally!
A note, a question or your personal view on the supplement – all are truly welcome. And sharing will always be sincerely appreciated.
Have An Awesome Day!