The core goal with this best vitamin B12 supplements 2021 article is to discuss without bias the genuinely best B12 products available on the market. This will be about finding the truth. This will be about discussing some BS supplements as well (those that other lists call the best but which aren’t really).
We’ll basically have three lists. One will be for general health and well-being. And one will be focused on people that are battling a deficiency (which can also easily be used for overall health as well). And the last will be about covering the options for vegans and vegetarians.
For this one, I like to believe I did some truly proper research.
I went over every single supplement that I could possibly find that primarily contained vitamin B12. Also, I looked at many various bestseller lists. Ultimately, I’m confident this will be one of the best lists for B12 ones out there.
The Buyer’s Guide | What Should We Look For In Our B12?
When It Comes To The Vitamin Amounts, Don’t Be Fooled By Daily Values
Many will try to say and convince you that the amount of 100% Daily Value (DV) or Nutrient Reference Values (NRV) – depending on where you live – is enough for good health.
Or to put it in other words, they’re saying that 2.4-2.5 micrograms of vitamin B12 daily are what you need for good health. However, this is not true at all. These amounts define how much you need of a nutrient to avoid disease [R, R, R].
Needless to say that avoiding disease and having peak performance are two entirely different things. The truth is that you will need much, much more of B12 if you want to have optimal health and peak performance [R, R, R].
For general well-being, according to the best practices for nutrient amounts, we need between 500 and 1000 micrograms of vitamin B12 daily. So, this is also precisely what we should aim for with a proper standalone B12 vitamin.
Whereas for people battling deficiencies, it will typically be a different approach. For them, it will be about seriously getting that extra B12. Because it’s so incredibly important for our long-term health. And so, I believe dosages between 2500 and 5000 micrograms a day for the short-term can work wonders [R, R, R, R].
But fascinatingly, even dosages as high as that daily have failed to show any negative side-effects as far as long-term use. So, whichever potency feels more right to you, I feel you can’t really go wrong with it [R, R, R, R].
There Are Many Different Forms But Aim For Methylcobalamin & Adenosylcobalamin
And then there’s also Adenosylcobalamin. Although it’s one of the bioavailable forms (forms that our body does not need to convert to use), it’s very uncommon in supplements. Generally, because it’s a very unstable form [R, R, R, R].
From the three I mentioned before, Cyanocobalamin is the synthetic version of things.
Although, it’s pretty good at curing deficiencies, when converting to usable forms it releases cyanide molecules. Which basically needs to be detoxified, so energy must be expended to remove it [R, R, R, R, R].
It’s incredibly cheap to produce. And many try to advocate that it’s the most beneficial form (this is especially in regards to those manufacturers, which use it in their supplements). However, that’s not true at all [R, R, R, R].
Then there’s Hydroxocobalamin, which many believe is the best form for vitamin B12. This is because it’s one of the most common vitamin B12 forms that can be found in food naturally. And also our bodies convert it both into Methylcobalamin and Adenosylcobalamin – both of which are the bioavailable forms of the vitamin [R, R, R].
And sure, while it does offer some quite extraordinarily beneficial effects that other forms don’t, for some, it can turn out to be quite useless. Because of probable difficulties converting it properly, which is reliant on many factors, especially digestive health. Surprisingly this problem is more common than people might think [R, R, R].
Lastly, there’s Methylcobalamin, which is praised by many.
It’s available to our bodies for use immediately after consumption. It plays a vital role in detoxification. And it does loads of other cool stuff. Furthermore, Methylcobalamin is also the form of the vitamin that babies acquire most of any other cobalamins through mother’s milk [R, R, R, R, R, R, R].
So, overall, the best vitamin B12 supplements 2021 should have Methylcobalamin as their primary B12 form. Then if it’s possible any traces of Adenosylcobalamin are also welcome. As for Hydroxocobalamin, it’s also fine and one can definitely experiment with it for that slightly different benefit profile.
Whereas as for Cyanocobalamin, it’s not necessarily bad. It can still provide a significant benefit if used in appropriate amounts. It is, however, supposedly the least valuable form of the four.
It’s worth mentioning that there are also other forms of vitamin B12 in existence, like Chlorocobalamin, Nitrocobalamin, as well as many others. However, these are virtually impossible to come across in supplements.
Potentially Harmful Additives Are The Mark Of Not The Best Of Product
Many assume out of ignorance that additives do not matter, that the only thing that matters is the active ingredient (in this case, that vitamin B12). However, it’s not like that at all (learn more here).
Having harmful additives in our supplements promises to be not only taxing on the body but are also likely to cause serious side effects. Which more often than not will occur in the long-term, however, at times can also be experienced in short-term use.
Whereas harmless additives are nothing of that sort. Sure, the possibility of some minor side effects (mostly because of random allergies) for select few people can’t ever be ruled out entirely. But that’s just the nature of things.
So, to kind of paraphrase it, with the best vitamin B12 supplements for 2021, for sure, bad, shady, questionable additives must not be a part of them.
The Supplement Has To Enjoy Awesome Quality, Otherwise What’s The Point?
Quality and manufacturing is an aspect that goes beyond just the supplement label. Both tend to strongly rely on the integrity of the manufacturer. And it’s often an extremely tricky topic.
There’s a lot that goes into this. And so, it’s kind of very difficult to teach or always fully explain.
But, ideally, the quality should not only be predictable. The supplements should be to the very least in-house tested for purity and potency. But the pinnacle of quality, of course, is third-party testing.
And then, any other third-party certifications the B12 product may have, of course, are a good indication of more quality. And so, the more of those, the better.
Lastly, to compare, low-quality supplements can offer quite an unpredictable variety of side effects because of various impurities and other nonsense that may happen during manufacturing. Therefore, it’s critical to choose as high-quality supplements as possible.
It Can’t Be Price Unreasonably, A Pricey, No-Value Vitamin B12 Won’t Work For Us
This last one kind of speaks for itself. I mean, it may be pretty obvious, but it’s still worth mentioning. The price is something that, for sure, also must be taken into account.
Great vitamin B12 supplements at times can be overpriced, but that’s not common at all. In fact, oftentimes the poor quality ones are those that we overpay for. I mean, they’re cheaper than the quality options, that’s for sure. But they also provide little to no value.
And so, the final price per microgram of B12 is usually far, far worse.
An Aspect To Genuinely Ignore & We Do These Just For That One Vitamin
From time to time, vitamin B12 supplements involve other substances. Sometimes those are extra vitamins, other times those are random minerals, or sometimes it’s even about completely wild extra beneficial substances. I’ve seen a few lists putting unnecessary emphasis on those.
But to me, that makes no sense.
If we want other vitamins and minerals, then a proper multivitamin should be our course of action. If other beneficial substances are what we play for, then we rather need a list for energy supplements or something like that. This list is not a place for that.
That being said, I can’t ignore the following thing. If everything else is more or less the same, supplements that offer some additional beneficial substances or nutrients should be valued higher. Because they’re more value.
But it’s essential not to go crazy with this because then I feel we’re kind of losing the whole purpose of this list.
23 Best Vitamin B12 Supplements For Battling A Deficiency In 2021
No. 1 | LiveWell Vegan B12 (Review) – The Best Overall No Doubt At All
There are not a lot of supplements that I get truly excited about. But the LiveWell Vegan B12 is definitely one of them.
I’m not planning on fanboying out here. It’s just a genuinely great supplement. I mean, it just checks every box we should ever care about and want from a B12 supplement.
For active ingredients, it offers 5000 micrograms of Methylcobalamin per every 1 milliliter of the dropper. So, amazing for battling a deficiency. And very promising for benefits like better energy levels, immune function, and sleep, improved mood, and even promoting memory and brain function, as well as every other gain associated with B12 in the book [R, R, R, R, R].
All of that comes without any thought or concern about side effects. Because as far as additives, it comes only with those that are either harmless or slightly beneficial. But, the way I see it, the best part with LiveWell Vegan B12 is the quality [R, R, R, R, R, R, R, R].
It’s third-party tested for purity, potency, and safety. Plus, it’s Soy-Free, Gluten-Free, Dairy-Free, Non-GMO, and it comes with a 365-day money-back guarantee. Whereas for the price, sure, it’s not the cheapest. But I believe it’s just immense value. I mean, I’m confident you won’t find such quality for such a good price [R].
As for purchasing options, fakes with Amazon is just too high of a risk. So, I would only recommend getting directly from the manufacturer. Furthermore, it’s cheaper there. And they don’t have to pay stupid commissions for selling on Amazon then. So, more for them to boost their mission, be great, and deliver more value to us.
No. 2 | Global Healing Center B12 Tri-Blend (Review) – The Most Diverse Approach
This next one is arguably the most diverse, worthwhile, daring B12 option out there. The Global Healing Center B12 Tri-Blend offers three forms of the vitamin in a quality way.
So, this one offers 5000 micrograms of vitamin B12 per 1 milliliter. But it’s not all Methylcobalamin. Instead, it’s only 60% or 3000 micrograms of that. Then, it’s 20% or 1000 micrograms of Adenosylcobalamin and 20% or 1000 micrograms of Hydroxocobalamin. So, an absolute powerhouse of B12s, the way I see it.
To that end, not only will it be amazing when battling a deficiency, it will be amazing for all the gains they promise (like energy levels, cardiovascular health, the nervous system health) and beyond. Furthermore, it will arguably be an even slightly more diverse potential benefit profile due to the Cobalamin form variety. And great additives [R, R, R, R, R].
In addition to all that, the quality of the Global Healing Center B12 Tri-Blend with their in-house testing should be superb, from what I can tell. Which is only further emphasized by the fact that the thing is USDA Organic-certified, Gluten-Free, Non-GMO, Dairy-Free, and Soy-Free [R, R].
As for why this Tri-Blend is #2 and not #1, there are two things. First, in terms of the price, it’s kind of more than twice the cost. Second, the quality is high but I don’t feel it is as high as what third-party testing offers.
As for purchasing options, Amazon is a no-go. Directly from the manufacturer is I believe the best choice. Plus, it supports them the most not having to pay selling commissions. Plus, they offer subscription discounts and free-shipping along with a 365-day money-back guarantee (and free-shipping on returns as well).
No. 3 | Global Healing Center B12 Blend (Vegansafe B12) – Still An Extremely Viable One
This next B12 Blend used to go by the name of Vegansafe B12. It’s another one by the Global Healing Center. In fact, this was their very first vitamin B12 attempt. And it was an extremely well-received one. Not only that, it still is.
This thing offers 2500 micrograms of vitamin B12. But similarly, as it is with the Tri-Blend, this one is also not 100% Methylcobalamin. Instead, it’s 80% of that form (hence, 2000 micrograms), and, then, 20% extra of the Adenosylcobalamin (namely, 500 micrograms). That’s per every milliliter of the product.
As for the gains, the amount despite being two times less is very potent nonetheless. Not only will it be great for effectively fighting a deficiency, but also it will be very capable in delivering on all those benefits they talk about (like provides more energy, improves nervous system function, supports cardiovascular health). And beyond [R, R, R, R, R].
Just as with the company’s Tri-Blend B12, the additives are great. The quality is also. This too is in-house tested, USDA Organic-certified, GMO-Free, Dairy-Free, Gluten- and Soy-Free wonder that comes with a 365-day money-back guarantee and free-shipping in every direction [R, R].
As for why this is #3 and not #2, it’s just the all-around less powerful option. Whereas as far as purchasing options, all of the same applies. Amazon is a bad option, best to get it from the manufacturer directly. It certainly helps them most with the mission, philosophy, and everything.
No. 4 | Vimergy Liquid B12
No. 5 | Now Foods Methyl B-12 5,000 mcg Vegetable Capsules – Best Capsules
No. 6 | Why Not Natural Organic Methylcobalamin B12
No. 7 | Bluebonnet Nutrition EarthSweet Chewables CellularActive Methylcobalamin – Best Chewables & Gummy
No. 8 | Nature Provides Bioactive B12
No. 9 | Wild Fuel Vegan B12
No. 10 | Selfe Beet 12 – Best Powder
No. 11 | Doctor’s Best Fully Active B12
No. 12 | PuraTHRIVE Micelle Liposomal B12
No. 13 | Nutricost Vitamin B12 (Methylcobalamin)
No. 14 | VitaBright High Strength Vitamin B12
No. 15 | Natural Factors Methylcobalamin 5,000 Mcg
No. 16 | Superior Source Methylcobalamin B-12 5,000 mcg
No. 17 | Go Nutrients Vitamin B12
No. 18 | Nutroliq Vitamin B12
No. 19 | SBR Nutrition Vitamin B12
No. 20 | Bioclinic Naturals B12 Methylcobalamin 5,000 mcg
No. 21 | Pinnacle Nutrition Vitamin B12
No. 22 | Vita Logic Blast B-12 5,000 mcg
No. 23 | KAL B12 5,000 Mcg Timed-Release
19 Best Vitamin B12 Supplements For General Health In 2021
No. 1 | LiveWell Vegan B12 (Review) – This Is What I Would Pick Still For General Health
Okay. So, I did not intend to put the LiveWell Vegan B12 one here as well. But the more I thought about it, the more sense it made. This one’s truly that good. Furthermore, it’s not like this B12 is a capsule that we can’t really divide the amount of. This one’s extremely flexible that way due to its way of serving (1 milliliter via a dropper).
As mentioned earlier, this offers 5000 micrograms of vitamin B12. It’s how much we get per 1 milliliter. But because it’s a dropper, it’s possible (and very easy) to divide that to less.
Say, is 2500 micrograms what you would like to do daily instead? Do roughly half of what the dropper marks as that one milliliter. Or better yet, is 1000 micrograms daily what you’re after? Do roughly one-fifth of what is marked as 1 one milliliter. Or have it any other way (amount) you deem fit for your exact needs.
Moreover, it doesn’t really matter that it won’t be exact. It’s not like we can get it to harmful levels even with 5000 micrograms daily for a seriously long period of time. I mean, yes, it probably isn’t the amount necessary but we can definitely feel free to experiment with it from time to time [R, R, R, R].
But all of that aside, here’s the really awesome part. Using just about one-fifth of the dropper will make it so that it will last for about 300 days. That’s a little short of a year. I mean, the quality, the price for a year’s supply… Just busted [R].
I mean, I hope this makes sense now. For more details on this what I believe is the very best option, check back with the first section on it (by clicking here, it will scroll you back to it).
No. 2 | Thorne Research Methylcobalamin (Review) – Best Capsules For General Health
Since the beginning of time (well, almost), I’ve been a huge fan of Thorne Research. That has been mainly the case due to the kind of quality and testing they subscribe. The standards of which I feel are genuinely among the very highest in the industry.
But not only do they exceed many of the stringiest of quality standards set around the world but also their ingredient choices for their supplements are top-shelf. And so, naturally, we’ll have to have one on the list.
Per capsule, the Thorne Research Methylcobalamin offers 1000 micrograms of vitamin B12. So, the best form in reasonable amounts for all the benefits and general health. Solid. Very, very solid [R, R, R, R, R].
The additive-choice is also one of the very best ones with B12 supplements. Which, in essence, translates well into zero risk for side-effects and even some slight added benefits due to them [R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R].
As far as price, it’s decent given the quality. Whereas as far as purchasing options, the default to Amazon won’t be a good one. Either get it directly or pick one of the most reliable supplements-selling platforms – iHerb. Personally, I would pick the latter.
No. 3 | Naturelo Vegan B12 (Review) – Adding Spirulina To The Mix
No. 4 | Bluebonnet Nutrition EarthSweet Chewables Methylcobalamin 1000 mcg – Best Chewables & Gummy
No. 5 | Doctor’s Best Energy+ – Best Unconventional (Extra Energy)
No. 6 | Live Wise Vitamin B12 Bioactive Blend
No. 7 | Life Extension BioActive Folate & Vitamin B12
No. 8 | Sigform Vitamin B12
No. 9 | Trace Minerals Ionic B12
No. 10 | WeightWorld Vitamin B12
No. 11 | Omvits Vitamin B12
No. 12 | Nu U Nutrition Vitamin B12
No. 13 | NutraVita Vitamin B12
No. 14 | Natural Factors B12 Methylcobalamin 1,000 mcg
No. 15 | Superior Source Methylcobalamin B-12
No. 16 | Incite Vitamin B12 Methylcobalamin
No. 17 | Vital Nutrients Vitamin B12
No. 18 | Nutri-Ark Vitamin B12
No. 19 | MegaFood Vegan B12
11 Best Vitamin B12 Supplements For Vegans & Vegetarians In 2021
No. 1 | LiveWell Vegan B12
No. 2 | Global Healing Center B12 Tri-Blend
No. 3 | Global Healing Center B12 Blend (Vegansafe)
No. 4 | Vimergy Liquid B12
No. 5 | Now Foods Methyl B-12 5,000 mcg Vegetable Capsules
No. 6 | Why Not Natural Organic Methylcobalamin B12
No. 7 | Bluebonnet Nutrition EarthSweet Chewables CellularActive Methylcobalamin
No. 8 | Naturelo Vegan B12
No. 9 | Bluebonnet Nutrition EarthSweet Chewables Methylcobalamin 1000 mcg
No. 10 | Doctor’s Best Energy+
No. 11 | Live Wise Vitamin B12 Bioactive Blend
7 Bull*hit B12 Supplements – Don’t Fall For These
*** | Jarrow Formulas Methyl B-12 (Review)
*** | Garden of Life MyKind Organics B-12 Organic Spray (Review) – No More
*** | Garden of Life Vitamin Code RAW B-12 (Review) – Used To Be Amazing
*** | Nature’s Plus Vitamin B-12 2000 mcg (Review)
*** | Pure Encapsulations B12 Folate (Review)
*** | Pure Encapsulations Adenosyl/Hydroxy B12 (Review)
*** | CCL Advanced Vitamin B12 Complex (Review)
This article was heavily updated on December 14, 2020.